Jorg Goronzy

Publication Details

  • T cell subset-specific susceptibility to aging CLINICAL IMMUNOLOGY Czesnikiewicz-Guzik, M., Lee, W., Cui, D., Hiruma, Y., Lamar, D. L., Yang, Z., Ouslander, J. G., Weyand, C. M., Goronzy, J. J. 2008; 127 (1): 107-118

    Abstract:

    With increasing age, the competence of the immune system to fight infections and tumors declines. Age-dependent changes have been mostly described for human CD8 T cells, raising the question of whether the response patterns for CD4 T cells are different. Gene expression arrays of memory CD4 T cells yielded a similar age-induced fingerprint as has been described for CD8 T cells. In cross-sectional studies, the phenotypic changes were not qualitatively different for CD4 and CD8 T cells, but occurred much more frequently in CD8 T cells. Homeostatic stability partially explained this lesser age sensitivity of CD4 T cells. With aging, naïve and central memory CD8 T cells were lost at the expense of phenotypically distinct CD8 effector T cells, while effector CD4 T cells did not accumulate. However, phenotypic shifts on central memory T cells were also more pronounced in CD8 T cells. This distinct stability in cell surface marker expression can be reproduced in vitro. The data show that CD8 T cells are age sensitive by at least two partially independent mechanisms: fragile homeostatic control and gene expression instability in a large set of regulatory cell surface molecules.

    View details for DOI 10.1016/j.clim.2007.12.002

    View details for Web of Science ID 000254501700013

    View details for PubMedID 18222733

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