Andrew J. Patterson, M.D., Ph.D.
Publication Details
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Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor.
Anesth Analg. 2009; (1): 280-7
Several beta-adrenergic receptor (betaAR) antagonists have been shown to have neuroprotective effects against cerebral ischemia. However, clenbuterol, a beta(2)AR agonist, was shown to have neuroprotective activity by increasing nerve growth factor expression. We used beta(2)AR knockout mice and a beta(2) selective antagonist to test the effect of loss of beta(2)ARs on outcome from transient focal cerebral ischemia.
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