John W. Day, MD, PhD

Publication Details

  • Myotonic dystrophy type 2 in Japan: ancestral origin distinct from Caucasian families NEUROGENETICS Saito, T., Amakusa, Y., Kimura, T., Yahara, O., Aizawa, H., Ikeda, Y., Day, J. W., Ranum, L. P., Ohno, K., Matsuura, T. 2008; 9 (1): 61-63


    Myotonic dystrophy type 2 (DM2) is caused by expansion of a tetranucleotide CCTG repeat in intron 1 of the ZNF9 gene on chromosome 3q21. All studied DM2 mutations have been reported in Caucasians and share an identical haplotype, suggesting a common founder. We identified a Japanese patient with DM2 and showed that the affected haplotype is distinct from the previously identified DM2 haplotype shared among Caucasians. These data strongly suggest that DM2 expansion mutations originate from separate founders in Europe and Japan and are more widely distributed than previously recognized.

    View details for DOI 10.1007/s10048-007-0110-4

    View details for Web of Science ID 000252638800007

    View details for PubMedID 18057971

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