Glenn Rosen

Publication Details

  • Ambient particulate matter induces alveolar epithelial cell cycle arrest: Role of G1 cyclins FEBS LETTERS Zhang, J., Ghio, A. J., Gao, M., Wei, K., Rosen, G. D., Upadhyay, D. 2007; 581 (27): 5315-5320

    Abstract:

    We hypothesized that the ambient air pollution particles (particulate matter; PM) induce cell cycle arrest in alveolar epithelial cells (AEC). Exposure of PM (25microg/cm(2)) to AEC induced cells cycle arrest in G1 phase, inhibited DNA synthesis, blocked cell proliferation and caused decrease in cyclin E, A, D1 and Cyclin E- cyclin-dependent kinase (CDK)-2 kinase activity after 4h. PM induced upregulation of CDK inhibitor, p21 protein and p21 activity in AEC. SiRNAp21 blocked PM-induced downregulation of cyclins and AEC G1 arrest. Accordingly, we provide the evidence that PM induces AEC G1 arrest by altered regulation of G1 cyclins and CDKs.

    View details for DOI 10.1016/j.febslet.2007.10.020

    View details for Web of Science ID 000253487700023

    View details for PubMedID 17977533

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