Lawrence Steinman

Publication Details

  • Antigen-specific therapy of multiple sclerosis: The long-sought magic bullet NEUROTHERAPEUTICS Steinman, L. 2007; 4 (4): 661-665


    The adaptive immune response in multiple sclerosis (MS) targets various myelin proteins and even some inducible heat shock proteins. A few attempts have been made to tolerize relapsing-remitting patients with MS to either full-length myelin basic protein or to a key peptide epitope between residues 83-99. These trials have demonstrated that this approach may potentially provide benefit to patients with relapsing- remitting MS. However, manipulation of responses to myelin proteins can have deleterious effects. The immune response to myelin components is positioned at a key tipping point in the pathophysiology of the disease. Clarification of the key target antigens in MS, and better understanding of practical methods to attain tolerance to a wide variety of myelin and neuronal molecules will provide the basis for the ultimately successful antigen specific therapy.

    View details for Web of Science ID 000250300400011

    View details for PubMedID 17920547

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