Glenn Rosen

Publication Details

  • Bim mediates mitochondria-regulated particulate matter-induced apoptosis in alveolar epithelial cells FEBS LETTERS Zhang, J., Ghio, A. J., Chang, W., Kamdar, O., Rosen, G. D., Upadhyay, D. 2007; 581 (22): 4148-4152


    We studied the role of Bim, a pro-apoptotic BCL-2 family member in Airborne particulate matter (PM 2.5 microm)-induced apoptosis in alveolar epithelial cells (AEC). PM induced AEC apoptosis by causing significant reduction of mitochondrial membrane potential and increase in caspase-9, caspase-3 and PARP-1 activation. PM upregulated pro-apoptotic protein Bim and enhanced translocation of Bim to the mitochondria. ShRNABim blocked PM-induced apoptosis by preventing activation of the mitochondrial death pathway suggesting a role of Bim in the regulation of mitochondrial pathway in AEC. Accordingly, we provide the evidence that Bim mediates PM-induced apoptosis via mitochondrial pathway.

    View details for DOI 10.1016/j.febslet.2007.07.080

    View details for Web of Science ID 000249476900004

    View details for PubMedID 17716672

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