C. Garrison Fathman

Publication Details

  • Molecular mechanisms of CD4(+) T-cell anergy NATURE REVIEWS IMMUNOLOGY Fathman, C. G., Lineberry, N. B. 2007; 7 (8): 599-609


    Directing both innate and adaptive immune responses against foreign pathogens with correct timing, location and specificity is a fundamental objective for the immune system. Full activation of CD4+ T cells requires the binding of peptide-MHC complexes coupled with accessory signals provided by the antigen-presenting cell. However, aberrant activation of the T-cell receptor alone in mature T cells can produce a long-lived state of functional unresponsiveness, known as anergy. Recent studies probing both immune signalling pathways and the ubiquitin-proteasome system have helped to refine and elaborate current models for the molecular mechanisms underlying T-cell anergy. Controlling anergy induction and maintenance will be a key component in the future to mitigate unwanted T-cell activation that leads to autoimmune disease.

    View details for DOI 10.1038/nri2131

    View details for Web of Science ID 000248394100012

    View details for PubMedID 17612584

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