David A. Relman

Publication Details

  • Organization, structure, and variability of the rRNA operon of the Whipple's disease bacterium (Tropheryma whippelii) JOURNAL OF BACTERIOLOGY Maiwald, M., Von Herbay, A., Lepp, P. W., Relman, D. A. 2000; 182 (11): 3292-3297


    Whipple's disease is a systemic disorder associated with a cultivation-resistant, poorly characterized actinomycete, Tropheryma whippelii. We determined a nearly complete rRNA operon sequence of T. whippelii from specimens from 3 patients with Whipple's disease, as well as partial operon sequences from 43 patients. Variability was observed in the 16S-23S rRNA spacer sequences, leading to the description of five distinct sequence types. One specimen contained two spacer sequence types, raising the possibility of a double infection. Secondary structure models for the primary rRNA transcript and mature rRNAs revealed rare or unique features.

    View details for Web of Science ID 000086988000042

    View details for PubMedID 10809715

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