Bryan Sun

Publication Details

  • X-chromosome kiss and tell: How the Xs go their separate ways COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY Anguera, M. C., Sun, B. K., Xu, N., Lee, J. T. 2006; 71: 429-437


    Loci associated with noncoding RNAs have important roles in X-chromosome inactivation (XCI), the dosage compensation mechanism by which one of two X chromosomes in female cells becomes transcriptionally silenced. The Xs start out as epigenetically equivalent chromosomes, but XCI requires a cell to treat two identical X chromosomes in completely different ways: One X chromosome must remain transcriptionally active while the other becomes repressed. In the embryo of eutherian mammals, the choice to inactivate the maternal or paternal X chromosome is random. The fact that the Xs always adopt opposite fates hints at the existence of a trans-sensing mechanism to ensure the mutually exclusive silencing of one of the two Xs. This paper highlights recent evidence supporting a model for mutually exclusive choice that involves homologous chromosome pairing and the placement of asymmetric chromatin marks on the two Xs.

    View details for Web of Science ID 000245962800054

    View details for PubMedID 17381325

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