Krisa Van Meurs

Publication Details

  • Early inhaled nitric oxide therapy for term and near-term newborn infants with hypoxic respiratory failure: Neurodevelopmental follow-up JOURNAL OF PEDIATRICS Konduri, G. G., Vohr, B., Robertson, C., Sokol, G. M., Solimano, A., Singer, J., Ehrenkranz, R. A., Singhal, N., Wright, L. L., Van Meurs, K., Stork, E., Kirpalani, H., Peliowski, A., Johnson, Y. 2007; 150 (3): 235-240


    To report the neurodevelopmental outcome of infants enrolled in a randomized multicenter trial of early inhaled nitric oxide (iNO) in term and near-term neonates with hypoxic respiratory failure and pulmonary hypertension.Neonates born at > or = 34 weeks gestation who required assisted ventilation and had an oxygenation index > or = 15 and < 25 were randomized to an early iNO group or a control group. A comprehensive neurodevelopmental assessment of survivors was performed at age 18 to 24 months.The trial enrolled 299 infants, of which 266 (89%) survived to age 18 to 24 months (136 in the early iNO group and 130 in the control group). Follow-up evaluations were done on 234 (88%) of surviving infants. There were no differences between the 2 groups in the incidence of neurodevelopmental impairment (early iNO, 27%; control, 25%) and hearing impairment (early iNO, 23%; control, 24%). Mental development index scores were similar in the 2 groups; however, psychomotor developmental index scores were significantly higher in the control group (early iNO, 89 +/- 17.7; control, 93.5 +/- 18.4).Early iNO therapy for hypoxic respiratory failure in term and near-term infants is not associated with an increase in neurodevelopmental impairment or hearing loss at 18 to 24 months postnatal age.

    View details for DOI 10.1016/j.jpeds.2006.11.065

    View details for Web of Science ID 000244629700009

    View details for PubMedID 17307536

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