Glenn Rosen

Publication Details

  • Fibroblast growth factor-10 prevents H2O2-induced cell cycle arrest by regulation of GI cyclins and cyclin dependent kinases FEBS LETTERS Upadhyay, D., Chang, W., Wei, K., Gao, M., Rosen, G. D. 2007; 581 (2): 248-252


    We studied the effects of fibroblast growth factor (FGF-10) on H2O2-induced alveolar epithelial cell (AEC) G1 arrest and the role of G1 cyclins. FGF-10 prevented H2O2-induced AEC G1 arrest. FGF-10 induced 2-4-fold increase in cyclin E, cyclin A and CDKs (2,4) alone and in AEC treated with H2O2. H2O2 downregulated cyclin D1; FGF-10 blocked these effects. FGF-10 prevented H2O2-induced upregulation of CDK inhibitor, p21. SiRNAp21 blocked H2O2-induced downregulation of cyclins, CDKs and AEC G1 arrest. Accordingly, we provide first evidence that FGF-10 regulates G1 cyclins and CDKs, and prevents H2O2-induced AEC G1 arrest.

    View details for DOI 10.1016/j.febslet.2006.12.020

    View details for Web of Science ID 000244188700012

    View details for PubMedID 17188682

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