Gary Schoolnik

Publication Details

  • The competitive cost of antibiotic resistance in Mycobacterium tuberculosis SCIENCE Gagneux, S., Long, C. D., Small, P. M., Van, T., Schoolnik, G. K., Bohannan, B. J. 2006; 312 (5782): 1944-1946


    Mathematical models predict that the future of the multidrug-resistant tuberculosis epidemic will depend on the fitness cost of drug resistance. We show that in laboratory-derived mutants of Mycobacterium tuberculosis, rifampin resistance is universally associated with a competitive fitness cost and that this cost is determined by the specific resistance mutation and strain genetic background. In contrast, we demonstrate that prolonged patient treatment can result in multidrug-resistant strains with no fitness defect and that strains with low- or no-cost resistance mutations are also the most frequent among clinical isolates.

    View details for DOI 10.1126/science.1124410

    View details for Web of Science ID 000238848100057

    View details for PubMedID 16809538

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