Mark Holodniy

Publication Details

  • Hepatitis C virus protease gene diversity in patients coinfected with human immunodeficiency virus JOURNAL OF VIROLOGY Winters, M. A., Welles, S. L., Holodniy, M. 2006; 80 (8): 4196-4199


    The clonal variability of the hepatitis C virus (HCV) protease gene in 24 individuals with HCV genotypes 1a, 1b, 2b, and 3a who were coinfected with the human immunodeficiency virus was evaluated. Within-genotype variability at the nucleotide and amino acid levels ranged from 6.5 to 8.6% and 2.2 to 3.8%, respectively. After adjustments were made for correlation of intrapatient clonal variation, mixed-model analysis indicated that nucleotide and amino acid variability among patients with different genotypes did not differ significantly. However, within individual patients, clonal variability differed by up to 5.3% and 5.8% at the nucleotide and amino acid levels, respectively, and genotype 1a had significantly greater nucleotide variability than other genotypes (P = 0.01). Significant variability exists within HCV protease gene variants at the patient level and could affect the effectiveness of HCV protease inhibitors.

    View details for DOI 10.1128/JVI.80.8.4196-4199.2006

    View details for Web of Science ID 000236685600053

    View details for PubMedID 16571838

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