Uta Francke

Publication Details

  • GENOMIC ORGANIZATION AND CHROMOSOMAL LOCALIZATION OF THE TAPA-1 GENE JOURNAL OF IMMUNOLOGY Andria, M. L., Hsieh, C. L., Oren, R., FRANCKE, U., Levy, S. 1991; 147 (3): 1030-1036

    Abstract:

    TAPA-1 is a 26-kDa integral membrane protein expressed on many human cell types. Antibodies against TAPA-1 induce homotypic aggregation of cells and can inhibit their growth. The murine homologue of TAPA-1 was cloned from both cDNA and genomic DNA libraries. A very high level of homology was found between human and mouse TAPA-1. The 5' untranslated region of the TAPA-1 gene resembles housekeeping gene promoters with respect to G + C content and the presence of potential Sp1 binding sites. The chromosomal localization of human and murine TAPA-1 genes was determined by Southern blot experiments using DNA from somatic cell hybrids. The genes were found to be part of a conserved syntenic group in mouse chromosome 7 and the short arm of human chromosome 11. The organization of the TAPA-1 gene and the projection of the exon boundaries on the proposed protein structure are presented.

    View details for Web of Science ID A1991FY29200041

    View details for PubMedID 1650385

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