C. Garrison Fathman

Publication Details

  • CD4(+)CD25(+) regulatory T cells and their therapeutic potential ANNUAL REVIEW OF MEDICINE Randolph, D. A., Fathman, C. G. 2006; 57: 381-402


    The human immune system mounts specific responses to a vast array of antigens. Although this is clearly beneficial in fighting off harmful infections and cancerous cells, the system must be carefully controlled to ensure that normal self-antigens are not targeted. A recently characterized subset of T cells, identified by their cell surface expression of CD4 and CD25, is critical in regulating the function of other immune cells and preventing potentially harmful autoimmune responses. This article reviews what is currently known about these so-called regulatory T cells and discusses the therapeutic potential of these cells to modulate human immune-based diseases.

    View details for DOI 10.1146/annurev.med.57.121304.131337

    View details for Web of Science ID 000235981900024

    View details for PubMedID 16409156

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