Mark Holodniy

Publication Details

  • Proteomic analysis of serum cytokine levels in response to highly active antiretroviral therapy (HAART) JOURNAL OF PROTEOME RESEARCH Relucio, K. I., Beernink, H. T., Chen, D., Israelski, D. M., Kim, R., Holodniy, M. 2005; 4 (2): 227-231


    A 30-cytokine protein microarray was used to screen for cytokine profile changes in HIV-infected patients in response to highly active antiretroviral therapy (HAART). Serum cytokines showing significant changes were confirmed by enzyme immunoassay. Monokine induced by gamma-interferon (MIG) and interferon-inducible protein-10 (IP-10) levels significantly decreased after 24 weeks of HAART. Protein microarrays are useful for initial screening of novel cytokine expression. Further studies are needed to elucidate the role of MIG and IP-10 in response to HAART.

    View details for DOI 10.1021/pr049930y

    View details for Web of Science ID 000228421900004

    View details for PubMedID 15822897

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