Victor W. Henderson

Publication Details

  • Postmenopausal hormone therapy and Alzheimer's disease risk: interaction with age JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Henderson, V. W., Benke, K. S., Green, R. C., Cupples, L. A., Farrer, L. A. 2005; 76 (1): 103-105


    We examined the relation between oestrogen containing hormone therapy (HT) used for more than 6 months and Alzheimer's disease (AD) risk in 971 postmenopausal women (426 AD patients, 545 relatives without dementia). There was a significant interaction between age and HT use on AD risk (p = 0.03). In stratified analyses, a significant protective association was seen only in the youngest age tertile (50-63 years; odds ratio = 0.35, 95% confidence interval = 0.19 to 0.66). Results must be considered cautiously in light of recent clinical trial evidence that oestrogen plus progestin increases dementia incidence in older postmenopausal women. However, our observational findings are consistent with the view that HT may protect younger women from AD or reduce the risk of early onset forms of AD, or that HT used during the early postmenopause may reduce AD risk.

    View details for DOI 10.1136/jnnp.2003.024927

    View details for Web of Science ID 000225777400021

    View details for PubMedID 15608005

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