Steven Shafer

Publication Details

  • In silico genetics: Identification of a functional element regulating H2-E alpha gene expression SCIENCE Liao, G. C., Wang, J. M., Guo, J. S., Allard, J., Cheng, J., Ng, A., Shafer, S., Puech, A., McPherson, J. D., Foernzler, D., Peltz, G., Usuka, J. 2004; 306 (5696): 690-695


    Computational tools can markedly accelerate the rate at which murine genetic models can be analyzed. We developed a computational method for mapping phenotypic traits that vary among inbred strains onto haplotypic blocks. This method correctly predicted the genetic basis for strain-specific differences in several biologically important traits. It was also used to identify an allele-specific functional genomic element regulating H2-Ealpha gene expression. This functional element, which contained the binding sites for YY1 and a second transcription factor that is probably serum response factor, is located within the first intron of the H2-Ealpha gene. This computational method will greatly improve our ability to identify the genetic basis for a variety of phenotypic traits, ranging from qualitative trait information to quantitative gene expression data, which vary among inbred mouse strains.

    View details for DOI 10.1126/science.1100636

    View details for Web of Science ID 000224756700053

    View details for PubMedID 15499019

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