C. Garrison Fathman

Publication Details

  • Gene therapy for type 1 diabetes: a novel approach for targeted treatment of autoimmunity JOURNAL OF CLINICAL INVESTIGATION Creusot, R. J., Fathman, C. G. 2004; 114 (7): 892-894

    Abstract:

    It has been difficult to develop therapies that target those T cells initiating and mediating the pathogenesis of autoimmune disease. Indeed, most current treatments indiscriminately affect both the autoreactive T cells and the "good" T cells, putting the patient at risk of compromised immune function. A new approach raises the possibility of targeted therapy for autoimmunity. Transplantation of hematopoietic stem cells modified to express a protective form of MHC class II corrects a defect in central tolerance. This method contrasts with other targeted therapies that attempt to modify peripheral tolerance, which is also defective in type 1 diabetes mellitus.

    View details for DOI 10.1172/JC1200423168

    View details for Web of Science ID 000224223800008

    View details for PubMedID 15467826

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