Michael Jeng

Publication Details

  • Natural history of moderate aplastic anemia in children PEDIATRIC BLOOD & CANCER Howard, S. C., Naidu, P. E., Hu, X. J., Jeng, M. R., Rodriguez-Gallindo, C., Rieman, M. D., Wang, W. C. 2004; 43 (5): 545-551


    Moderate aplastic anemia (MAA) in children is a rare, idiopathic condition of bone marrow insufficiency that can resolve spontaneously, persist for months or years, or progress to severe aplastic anemia (SAA). We evaluated the rate of progression to SAA.We reviewed the records of 136 children referred for evaluation of bone marrow failure from 1978 to 2002 at St. Jude Children's Research Hospital. MAA was defined by a hypocellular bone marrow (<50%) and 2 or 3 cytopenias (absolute neutrophil count <1,500/mm(3), absolute reticulocyte count <40,000/mm(3), platelet count <100,000/mm(3)) lasting at least 6 weeks.Twenty-four patients met the criteria for MAA. At a median follow-up of 66 months (range, 10-293), 16 patients (67%) progressed to SAA, 5 (21%) had persistent MAA, and 3 (12%) had complete resolution of MAA. No risk factors for progression could be identified.When childhood MAA is treated with supportive care alone, 2/3 of patients progress to SAA.

    View details for DOI 10.1002/pbc.20131

    View details for Web of Science ID 000224191300006

    View details for PubMedID 15382271

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