Glenn Rosen

Publication Details

  • Loss of STAT1 expression confers resistance to IFN-gamma-induced apoptosis in ME180 cells FEBS LETTERS Lee, K. Y., Anderson, E., Madani, K., Rosen, G. D. 1999; 459 (3): 323-326


    Interferon gamma (IFN-gamma) induces apoptosis in many tumor cell lines and sensitizes tumor cells to apoptosis by tumor necrosis factor family members. IFN-gamma induces the expression of many early response genes such as interferon regulatory factor-1 (IRF-1) by activation of signal transducer and activator of transcription (STAT) factor proteins. We found that ME180 cells became resistant to IFN-gamma-induced cell death after 4-5 passages in culture. These resistant cells were characterized by a loss of STAT1 expression and a loss of inducible IRF-1 expression. We describe for the first time the emergence of a STAT1-deficient ME180 cell line.

    View details for Web of Science ID 000083204500008

    View details for PubMedID 10526158

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