Julie Parsonnet

Publication Details

  • Prevalence and incidence of herpes simplex virus type 2 infection among male Zimbabwean factory workers McFarland, W., Gwanzura, L., Bassett, M. T., Machekano, R., Latif, A. S., Ley, C., Parsonnet, J., BURKE, R. L., KATZENSTEIN, D. UNIV CHICAGO PRESS. 1999: 1459-1465


    Stored sera from a cohort of 2397 male factory workers in Harare, Zimbabwe, were screened for herpes simplex virus type 2 (HSV-2)-specific antibodies, to estimate the prevalence and incidence of genital herpes infection and to assess the relation between HSV-2 and human immunodeficiency virus (HIV) acquisition. The prevalence of HSV-2 at enrollment was 39.8%. Correlates of HSV-2 seropositivity were HIV seropositivity, marital status, history of sexually transmitted disease (STD), older age, and higher income. The incidence of HSV-2 seroconversion during follow-up was 6.2/100 person-years. Correlates of HSV-2 seroconversion were enrollment while HIV-positive or seroconversion during follow-up, reported genital ulcer, history of STD, and number of sex partners. No evidence was found that HSV-2 infection was more likely to precede HIV or vice versa. HSV-2 and HIV seropositivity are strong markers for high-risk sexual behavior. Improved interventions targeted to populations in which the incidence of either viral infection is high are needed.

    View details for Web of Science ID 000083519500007

    View details for PubMedID 10515804

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