Paula Hillard

Publication Details

  • Comparison of adolescent and young adult self-collected and clinician-collected samples for human papillomavirus OBSTETRICS AND GYNECOLOGY Kahn, J. A., Slap, G. B., Huang, B., Rosenthal, S. L., Wanchick, A. M., Kollar, L. M., Hillard, P. A., Witte, D., Groen, P., BERNSTEIN, D. I. 2004; 103 (5): 952-959


    To examine the concordance between self-collected and clinician-collected samples for human papillomavirus (HPV) DNA.Sexually active adolescent and young adult women aged 14-21 years (N = 101) were enrolled in a prospective cohort study of HPV testing. Participants self-collected vaginal samples for HPV DNA, and clinicians collected cervicovaginal samples for HPV DNA and a cervical cytology specimen. We determined concordance between the results of self- and clinician-collected specimens using a kappa statistic and McNemar's test.Of the 51% of participants who were HPV positive, 53% had 1 type, 25% had 2 types, and 22% had 3 types or more; 25 different HPV types were identified. Self-collected samples detected more participants with HPV than clinician-collected samples (45% versus 42%, P =.65). When results were categorized into presence or absence of high-risk HPV types, agreement between self- and clinician-collected specimens was high (kappa 0.72) and the difference between test results was not significant (McNemar's P =.41). However, when all HPV types detected were considered, agreement was perfect in only 51% of those with 1 or more types of high-risk HPV type. There was no association between agreement and age or HPV type.Self testing for HPV DNA may be sufficiently sensitive for the detection of high-risk HPV DNA among adolescent and young adult women in clinical settings.

    View details for DOI 10.1097/01.AOG.0000124569.61462.8d

    View details for Web of Science ID 000225414200019

    View details for PubMedID 15121570

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