Eswar Krishnan, MD M.Phil

Publication Details

  • Measuring effectiveness of drugs in observational databanks: promises and perils ARTHRITIS RESEARCH & THERAPY Krishnan, E., Fries, J. F. 2004; 6 (2): 41-44


    Observational databanks have inherent strengths and shortcomings. As in randomized controlled trials, poor design of these databanks can either exaggerate or reduce estimates of drug effectiveness and can limit generalizability. This commentary highlights selected aspects of study design, data collection and statistical analysis that can help overcome many of these inadequacies. An international metaRegister and a formal mechanism for standardizing and sharing drug data could help improve the utility of databanks. Medical journals have a vital role in enforcing a quality checklist that improves reporting.

    View details for DOI 10.1186/ar1151

    View details for Web of Science ID 000189035200001

    View details for PubMedID 15059263

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