Stanley Schrier

Publication Details

  • The role of oxidant injury in the pathophysiology of human thalassemias REDOX REPORT Schrier, S. L., Centis, F., Verneris, M., Ma, L., Angelucci, E. 2003; 8 (5): 241-245


    The anemia in beta-thalassemia major is caused by a combination of hemolysis and ineffective erythropoiesis, with the latter being more important. Studies of the underlying cause of the hemolysis have indicated that oxidant injury to circulating red blood cells (RBCs) was of critical importance, with evidence of oxidant damage to RBC membrane proteins 4.1 and band 3. Therefore, it seemed reasonable that oxidant damage to thalassemic erythroid precursors would cause their accelerated apoptosis and ineffective erythropoiesis. However, direct analysis showed that the apoptotic programs turned on in thalassemics were not those triggered by oxidative damage but were dependent on activation of FAS/FAS-Ligand interaction. Thus, destruction of thalassemic erythroid precursors may involve different mechanisms from those that cause RBC hemolysis.

    View details for DOI 10.1179/135100003225002835

    View details for Web of Science ID 000187735400004

    View details for PubMedID 14962357

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