Rajnish Gupta

Publication Details

  • Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth NATURE MEDICINE Gupta, R. A., Wang, D. Z., Katkuri, S., Wang, H. B., Dey, S. K., DuBois, R. N. 2004; 10 (3): 245-247


    We treated Apc(min) mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-delta (PPAR-delta). Exposure of Apc(min) mice to the PPAR-delta ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-delta in the regulation of intestinal adenoma growth.

    View details for DOI 10.1038/nm993

    View details for Web of Science ID 000189297700034

    View details for PubMedID 14758356

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