Krisa Van Meurs

Publication Details

  • Nitrogen dioxide formation during inhaled nitric oxide therapy CLINICAL CHEMISTRY Sokol, G. M., Van Meurs, K. P., Wright, L. L., Rivera, O., Thorn, W. J., Chu, P. M., Sams, R. L. 1999; 45 (3): 382-387


    Nitrogen dioxide (NO2) is a toxic by-product of inhalation therapy with nitric oxide (NO). The rate of NO2 formation during NO therapy is controversial.The formation of NO2 was studied under dynamic flows emulating a base case NO ventilator mixture containing 80 ppm NO in a 90% oxygen matrix. The difficulty in measuring NO2 concentrations below 2 ppm accurately was overcome by the use of tunable diode laser absorption spectroscopy.Using a second-order model, the rate constant, k, for NO2 formation was determined to be (1.19 +/- 0.11) x 10(-11) ppm-2s-1, which is in basic agreement with evaluated data from atmospheric literature.Inhaled NO can be delivered safely in a well-designed, continuous flow neonatal ventilatory circuit, and NO2 formation can be calculated reliably using the rate constant and circuit dwell time.

    View details for Web of Science ID 000078979100009

    View details for PubMedID 10053039

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