James L. Zehnder, M.D.

Publication Details

  • Lymphomatoid papulosis associated with mycosis fungoides: A study of 21 patients including analyses for clonality JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY Zackheim, H. S., Jones, C., LeBoit, P. E., Kashani-Sabet, M., McCalmont, T. H., Zehnder, J. 2003; 49 (4): 620-623

    Abstract:

    Although an association of lymphomatoid papulosis (LyP) with mycosis fungoides (MF) is recognized, our understanding of this relation is limited.We sought to document the clinical experience at the University of California, San Francisco, in 21 patients who had both LyP and MF and to do clonality studies in 7 of those patients in whom this was possible.We conducted chart review of the 21 patients and analysis for T-cell receptor-gamma gene rearrangements by the polymerase chain reaction.Of 54 patients, 21 (39%) with LyP had associated MF. LyP preceded MF in 14 (67%), MF preceded LyP in 4 (19%), and there was concurrent appearance in 3 (14%). Of the 21 patients, 20 (95%) were type A and only 1 (5%) was type B. An identical clone was found in lesions of both LyP and MF in all 7 patients in whom analysis was possible.Findings of this study strengthen the idea that LyP and MF are related T-cell lymphoproliferative disorders.

    View details for DOI 10.1067/S0190-9622(03)01577-9

    View details for Web of Science ID 000185606500006

    View details for PubMedID 14512906

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