David A. Relman

Publication Details

  • PHYLOGENETIC-RELATIONSHIPS AMONG THE AGENT OF BACILLARY ANGIOMATOSIS, BARTONELLA-BACILLIFORMIS, AND OTHER ALPHA-PROTEOBACTERIA MOLECULAR MICROBIOLOGY Relman, D. A., Lepp, P. W., SADLER, K. N., Schmidt, T. M. 1992; 6 (13): 1801-1807

    Abstract:

    Bacillary angiomatosis (BA) and chronic bartonellosis are bacterial infections of humans which result in an unusual vascular proliferative tissue response. In order to determine their phylogenetic relationships, we have determined greater than 95% of the 16S rRNA sequences for these two organisms by amplification directly from infected BA tissue and from a Bartonella bacilliformis lyophilized culture. The BA agent and B. bacilliformis are closely related alpha-proteobacteria (98.5%), although the BA agent is more closely related to Rochalimaea quintana (99.1%). Contrary to previous belief, the BA agent is distinct from, and less closely related to, the cat scratch bacillus (Afipia felis) (90.7%). We propose a novel secondary structure in a hypervariable region of the 16S rRNA which is useful for alignment of primary sequences and which may be useful for design of nucleic acid probes.

    View details for Web of Science ID A1992JC20400009

    View details for PubMedID 1378524

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