Veronica Yank

Publication Details

  • An Easily Accessible Web-Based Minimization Random Allocation System for Clinical Trials JOURNAL OF MEDICAL INTERNET RESEARCH Xiao, L., Huang, Q., Yank, V., Ma, J. 2013; 15 (7): 279-288

    Abstract:

    Minimization as an adaptive allocation technique has been recommended in the literature for use in randomized clinical trials. However, it remains uncommonly used due in part to a lack of easily accessible implementation tools.To provide clinical trialists with a robust, flexible, and readily accessible tool for implementing covariate-adaptive biased-coin randomization.We developed a Web-based random allocation system, MinimRan, that applies Pocock-Simon (for trials with 2 or more arms) and 2-way (currently limited to 2-arm trials) minimization methods for trials using only categorical prognostic factors or the symmetric Kullback-Leibler divergence minimization method for trials (currently limited to 2-arm trials) using continuous prognostic factors with or without categorical factors, in covariate-adaptive biased-coin randomization.In this paper, we describe the system's essential statistical and computer programming features and provide as an example the randomization results generated by it in a recently completed trial. The system can be used in single- and double-blind trials as well as single-center and multicenter trials.We expect the system to facilitate the translation of the 3 validated random allocation methods into broad, efficient clinical research practice.

    View details for DOI 10.2196/jmir.2392

    View details for Web of Science ID 000324620300021

    View details for PubMedID 23872035

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