Daniel A. Arber, M.D.

Publication Details

  • Indolent T-lymphoblastic proliferation - Report of a case with a 16-year course without cytotoxic therapy AMERICAN JOURNAL OF SURGICAL PATHOLOGY Velankar, M. M., NATHWANI, B. N., Schlutz, M. J., Bain, L. A., Arber, D. A., Slovak, M. L., Weiss, L. M. 1999; 23 (8): 977-981


    T-lymphoblastic lymphoma is a high-grade malignant lymphoma. Clinically indolent T-lymphoblastic proliferations have not been described. We present a case report of an indolent T-cell lymphoblastic proliferation studied by histopathology, immunohistochemistry, flow cytometry, antigen receptor gene rearrangement studies, and cytogenetics. The patient had recurrent masses in the upper aerodigestive tract over a 16-year period, was treated by multiple surgical excisions, and never received either chemotherapy or radiotherapy. A proliferation of lymphoblasts was present histologically. The cells were positive for terminal deoxynucleotidyl transferase, CD1, and CD3, and coexpressed CD4 and CD8. No clonal rearrangements of the T-cell receptor beta or gamma chain genes were identified. Cytogenetic studies revealed a questionable inversion of the short arm of chromosome 9, affecting the 9p21-22 region. Although ectopic thymic tissue was considered, the case was considered to be an indolent lymphoblastic proliferation. It should be recognized that rare lymphoblastic proliferations may not behave in a high grade fashion as typically seen in T-lymphoblastic lymphoma.

    View details for Web of Science ID 000081740400017

    View details for PubMedID 10435569

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