Lawrence Steinman

Publication Details

  • [T-cell receptor repertoire in tumor infiltrating lymphocytes within malignant brain tumors]. No shinkei geka. Neurological surgery NITTA, T., Ikeda, M., Cogen, P., Steinman, L., Sato, K. 1992; 20 (5): 559-566


    Expression of T cell receptor (TCR) V alpha and V beta genes in tumor infiltrating lymphocytes (TILs) within human malignant brain tumor was examined. Primers for 18 different human TCR V alpha and 21 V beta families were used to analyze TCRV-(D)-J-C gene rearrangements in TILs in 8 human malignant glioma specimens obtained at surgery. Using the polymerase chain reaction (PCR) method, we detected limited TCR variable region, V alpha gene expression in malignant glial tumors and also V alpha 7 and V alpha 12 TCR genes were preferentially expressed. Usage of TCR V beta gene was not as restricted as in TCR V alpha. These TILs expressing a limited repertoire of TCRs might be isolated, expanded, and used therapeutically for treatment of malignant brain tumors.

    View details for PubMedID 1317945

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