Richard B. Moss

Publication Details

  • CHRONIC PSEUDOMONAS-AERUGINOSA ENDOBRONCHITIS IN RHESUS-MONKEYS .1. EFFECT OF PENTOXIFYLLINE ON NEUTROPHIL INFLUX JOURNAL OF MEDICAL PRIMATOLOGY Cheung, A. T., Moss, R. B., Leong, A. B., NOVICK, W. J. 1992; 21 (7-8): 357-362

    Abstract:

    Host defense abnormalities in cystic fibrosis (CF) against Pseudomonas aeruginosa (PA) lead to excessive neutrophil influx into the infected lungs, resulting in pulmonary complications. We have developed a rhesus monkey model of chronic PA endobronchitis by intrabronchial instillation of PA-embedded agar beads, utilizing flexible fiberoptic bronchoscopy. Treatment of infected monkeys with pentoxifylline suppressed neutrophil influx and ameliorated pulmonary damage. The results suggest a method by which neutrophil influx and pulmonary damage in CF patients can be managed or prevented.

    View details for Web of Science ID A1992LH16500004

    View details for PubMedID 1307753

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