Philip Oyer

Publication Details

  • SURVIVAL OF PRIMATES FOLLOWING ORTHOTOPIC CARDIAC TRANSPLANTATION TREATED WITH TOTAL LYMPHOID IRRADIATION AND CHEMICAL IMMUNE SUPPRESSION TRANSPLANTATION Pennock, J. L., Reitz, B. A., BIEBER, C. P., Aziz, S., Oyer, P. E., Strober, S., Hoppe, R., KAPLAN, H. S., Stinson, E. B., Shumway, N. E. 1981; 32 (6): 467-473

    Abstract:

    Fractionated total lymphoid irradiation (TLI) has been used for attempts at induction of a donor-specific tolerant-like state in allograft recipients and for immunosuppressive effects. Cyclosporin A (Cy A) has been shown to suppress rejection of organ grafts in many species including man. The present study was designed to test the effectiveness of TLI in combination with either CY A or rabbit anticynomolgus thymocyte globulin (ATG) and azathioprine. Thirty-one orthotopic cardiac allografts were performed using surface cooling and total circulatory arrest in outbred cynomolgus monkeys. TLI was administered preoperatively in fractions of 100 rad until a total of 600 or 1800 rad was achieved. Cy A was administered 17 mg/kg/day. All treatment groups demonstrated extended survival. Myocardial biopsies as early as 4 weeks were consistent with mild rejection in all treatment groups. No significant synergistic effect upon survival could be demonstrated utilizing TLI plus Cy A when compared with using Cy A alone. TLI (1800 rad) plus ATG and azathioprine was associated with a high incidence of early death attributable to leukopenia and infection. Cy A alone or in combination with TLI was associated with the development of lymphoid malignancy.

    View details for Web of Science ID A1981MU64300003

    View details for PubMedID 7041345

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