Jane C. Tan

Publication Details

  • Determinants of glomerular hypofiltration in aging humans KIDNEY INTERNATIONAL Hoang, K., Tan, J. C., Derby, G., Blouch, K. L., Masek, M., Ma, I., Lemley, K. V., Myers, B. D. 2003; 64 (4): 1417-1424


    The purpose of the present study was to confirm the extent to which glomerular filtration rate (GFR) is depressed in healthy, aging subjects and to elucidate the mechanism of such hypofiltration.Healthy volunteers aged 18 to 88 years (N = 159) underwent a determination of GFR, renal plasma flow (RPF), afferent oncotic pressure, and arterial pressure. Glomeruli in renal biopsies of healthy kidney transplant donors aged 23 to 69 years (N = 33) were subjected to a morphometric analysis, so as to determine glomerular hydraulic permeability and filtration surface area. The aforementioned GFR determinants were then subjected to mathematical modeling to compute the glomerular ultrafiltration coefficient (Kf) for two kidneys and individual glomeruli.GFR was significantly depressed (P < 0.0001) by 22% in aging (>or=55 years old) compared to youthful subjects (

    View details for Web of Science ID 000185226200031

    View details for PubMedID 12969161

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