Terence Ketter

Publication Details

  • Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder AMERICAN JOURNAL OF PSYCHIATRY Bowden, C. L., Calabrese, J. R., Ketter, T. A., Sachs, G. S., White, R. L., Thompson, T. R. 2006; 163 (7): 1199-1201

    Abstract:

    This study assessed weight changes in a large cohort of patients with bipolar disorder who were treated with randomly assigned maintenance monotherapies.A post hoc analysis was conducted to assess the effects of lamotrigine, lithium, and placebo administration on body weight in obese and nonobese patients with bipolar disorder from two double-blind, placebo-controlled, 18-month studies.Mean changes in weight among obese patients (N=155) at week 52 were -4.2, +6.1, and -0.6 kg with lamotrigine, lithium, and placebo, respectively (lamotrigine versus lithium and lithium versus placebo). Among nonobese patients (N=399), mean changes in weight (kg) at week 52 were -0.5, +1.1, and +0.7 with lamotrigine, lithium, and placebo, respectively, with no significant differences among groups.Obese patients with bipolar I disorder lost weight while taking lamotrigine and gained weight while taking lithium.

    View details for Web of Science ID 000238712000016

    View details for PubMedID 16816224

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