Peter J. Koltai MD, FACS, FAAP

Publication Details

  • Stepped-dose protocol of cidofovir therapy in recurrent respiratory papillomatosis in children ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY Akst, L. M., Lee, W., Discolo, C., Knott, D., Younes, A., Koltai, P. J. 2003; 129 (8): 841-846

    Abstract:

    To evaluate a stepped-dose protocol for intralesional injection of cidofovir in children with recurrent respiratory papillomatosis (RRP).Prospective, nonrandomized case series.Tertiary care children's hospital.Eleven children undergoing evaluation for RRP from June 1, 2000, through December 31, 2001.Intralesional injection of cidofovir was performed after microlaryngoscopy and carbon dioxide laser treatment. Patients received 4 monthly injections at a concentration of 5 mg/mL and returned 1 month after the last injection for follow-up. Patients with recurrent or recalcitrant disease then started a series of 4 monthly injections at a concentration of 10 mg/mL.Papilloma stage (0-3) documented at multiple subsites by means of serial microlaryngoscopy. We calculated a severity score by summing the scores at all affected subsites.The severity score decreased in each of the 11 patients during the course of therapy, from a mean +/- SD of 13.7 +/- 6.0 at enrollment to 2.1 +/- 3.4 at 1-month follow-up. Six patients experienced complete resolution (stage 0) and 4 others had mild disease (stage,

    View details for Web of Science ID 000184620100007

    View details for PubMedID 12925342

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