Samuel Strober

Publication Details

  • Early defect prethymic in bone marrow T cell progenitors in athymic nu/nu mice JOURNAL OF IMMUNOLOGY Chatterjea-Matthes, D., Garcia-Ojeda, M. E., Dejbakhsh-Jones, S., Jerabek, L., Manz, M. G., Weissman, I. L., Strober, S. 2003; 171 (3): 1207-1215


    nu/nu mice fail to develop a thymus and mature T cells due to a defect in the whn gene encoding a transcription factor necessary for terminal epithelial cell differentiation. We investigated whether early T cell progenitor development in the nu/nu bone marrow is also defective. We demonstrated a maturation arrest of nu/nu marrow T cell progenitors associated with a lack of pTalpha gene expression and a failure to give rise to mature T cells in adoptive euthymic hosts. Wild-type hemopoietic stem cells rapidly matured into functional T cell progenitors in the marrow of euthymic or thymectomized but not nu/nu hosts. We show that defects in bone marrow prethymic T cell development can also contribute to T cell deficiency in nu/nu mice.

    View details for Web of Science ID 000184327600012

    View details for PubMedID 12874207

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