Lawrence Steinman

Publication Details

  • Osteopontin polymorphisms and disease course in multiple sclerosis GENES AND IMMUNITY Caillier, S., Barcellos, L. F., Baranzini, S. E., Swerdlin, A., Lincoln, R. R., Steinman, L., Martin, E., Haines, J. L., Pericak-Vance, M., Hauser, S. L., Oksenberg, J. R. 2003; 4 (4): 312-315


    Osteopontin (OPN), also known as early T-cell activating gene (Eta-1), has been recently shown to be a critical factor in the progression of experimental autoimmune encephalomyelitis, and perhaps multiple sclerosis (MS). Here we investigated whether the 327T/C, 795C/T, 1128A/G or 1284A/C single-nucleotide polymorphisms in the OPN gene were correlated with susceptibility or any of the several clinical end points in a cohort of 821 MS patients. Overall, we observed no evidence of genetic association between the OPN polymorphisms and MS. Although not reaching statistical significance, a modest trend for association with disease course was detected in patients carrying at least one wild-type 1284A allele, suggesting an effect on disease course. Patients with this genotype were less likely to have a mild disease course and were at increased risk for a secondary-progressive clinical type.

    View details for DOI 10.1038/sj.gene.6363952

    View details for Web of Science ID 000183136100010

    View details for PubMedID 12761568

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