Geoffrey J. Yoon, M.D.

Publication Details

  • IMAGING AFTER GLIASITE BRACHYTHERAPY: PROGNOSTIC MRI INDICATORS OF DISEASE CONTROL AND RECURRENCE INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS Kleinberg, L., Yoon, G., Weingart, J. D., Parisi, M., Olivi, A., Detorie, N. A., Chan, T. A. 2009; 75 (5): 1385-1391

    Abstract:

    In this study, we analyzed the magnetic resonance imaging (MRI) changes in patients after GliaSite treatment and characterized the prognostic MRI indicators in these patients.A total of 25 patients with recurrent glioblastoma multiforme were treated with the GliaSite Radiation Therapy System. Patients at the Johns Hopkins Hospital with recurrent glioblastoma multiforme underwent surgical resection followed by GliaSite balloon implantation. Available MRI scans for 20 patients were obtained throughout the post-GliaSite treatment course. These were reviewed and analyzed for prognostic significance.After GliaSite treatment, all patients developed some degree of T(1)-weighted contrast and T(2)-weighted hyperintensity around the resection cavity. The development of enhancement on T(1)-weighted contrast-enhanced imaging and the size of these lesions, in the absence of increasing T(2)-weighted hyperintensity, before clinical progression was not associated with decreased survival. Patients with T(1)-weighted enhancement >1 cm had a median survival of 13.6 months and those with T(1)-weighted lesions

    View details for DOI 10.1016/j.ijrobp.2008.12.074

    View details for Web of Science ID 000272341800016

    View details for PubMedID 19394153

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