Jack Yu Jen Huang

Publication Details

  • Cryopreservation of ovarian tissue and in vitro matured oocytes in a female with mosaic Turner syndrome: Case Report HUMAN REPRODUCTION Huang, J. Y., TULANDI, T., Holzer, H., Lau, N. M., MacDonald, S., Tan, S. L., Chian, R. C. 2008; 23 (2): 336-339


    We report a novel approach of fertility preservation in a young woman with mosaic Turner syndrome. A 16-year-old female with 20% 45XO and 80% 46XX karyotype underwent laparoscopic ovarian wedge resection. Before performing ovarian tissue cryopreservation, all visible follicles on the ovarian surface were aspirated. We recovered 11 immature germinal vesicle stage oocytes, which were subjected to in vitro maturation (IVM). Eight oocytes that matured (73% maturation rate) were cryopreserved by vitrification. The combination of ovarian tissue cryobanking and immature oocyte collection from the tissue followed by IVM and vitrification of matured oocytes represent a promising approach of fertility preservation for young women with mosaic Turner syndrome.

    View details for DOI 10.1093/humrep/dem307

    View details for Web of Science ID 000252544300016

    View details for PubMedID 18056118

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