Brenda Porter

Publication Details

  • Focal cortical dysplasia is more common in boys than in girls EPILEPSY & BEHAVIOR Ortiz-Gonzalez, X. R., Poduri, A., Roberts, C. M., Sullivan, J. E., Marsh, E. D., Porter, B. E. 2013; 27 (1): 121-123


    Genetics and environment likely contribute to the development of medically intractable epilepsy; however, in most patients the specific combination of etiologies remains unknown. Here, we undertook a multicenter retrospective cohort study of sex distribution in pediatric patients undergoing epilepsy surgery and carried out a secondary analysis of the same population subdivided by histopathologic diagnosis. In the multicenter cohort of patients with intractable epilepsy undergoing surgery regardless of etiology (n=206), 63% were boys, which is significantly more boys than expected for the general population (Fisher exact two-tailed p=0.017). Subgroup analysis found that of the 90 patients with a histopathologic diagnosis of focal cortical dysplasia, 72% were boys, giving an odds ratio (OR) of 2.5 (95% CI, 1.34 to 4.62) for male sex. None of the other etiologies had a male sex predominance. Future studies could examine the biological relevance and potential genetic and pathophysiological mechanisms of this observation.

    View details for DOI 10.1016/j.yebeh.2012.12.035

    View details for Web of Science ID 000317029000022

    View details for PubMedID 23416281

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