Gary Schoolnik

Publication Details

  • Global stage-specific gene regulation during the developmental cycle of Chlamydia trachomatis JOURNAL OF BACTERIOLOGY Nicholson, T. L., Olinger, L., Chong, K., SCHOOLNIK, G., Stephens, R. S. 2003; 185 (10): 3179-3189


    Distinct morphological changes associated with the complex development cycle of the obligate intracellular bacterial pathogen Chlamydia trachomatis have been historically well characterized by microscopy. A number of temporally regulated genes have been characterized previously, suggesting that the chlamydial developmental cycle is regulated at the transcriptional level. This hypothesis was tested by microarray analysis in which the entire C. trachomatis genome was analyzed, providing a comprehensive assessment of global gene regulation throughout the chlamydial developmental cycle. Seven temporally cohesive gene clusters were identified, with 22% (189 genes) of the genome differentially expressed during the developmental cycle. The correlation of these gene clusters with hallmark morphological events of the chlamydial developmental cycle suggests three global stage-specific networks of gene regulation.

    View details for DOI 10.1128/JB.185.10.3179-3189.2003

    View details for Web of Science ID 000182686900024

    View details for PubMedID 12730178

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