Heike Daldrup-Link

Publication Details

  • Detection and quantification of breast tumor necrosis with MR imaging: Value of the necrosis-avid contrast agent Gadophrin-3 ACADEMIC RADIOLOGY Metz, S., Daldrup-Link, H. E., Richter, T., Rath, C., Ebert, W., Settles, M., Rummeny, E. J., Link, T. M., Piert, M. 2003; 10 (5): 484-490


    The authors evaluated the use of T1-weighted magnetic resonance (MR) imaging with Gadophrin-3 enhancement and of plain T2-weighted MR imaging to detect and quantify breast tumor necrosis.Twenty EMT-6 tumors (mouse mammary sarcoma), implanted into the mammary fat pad of BALB/c-AnNCrl mice, underwent MR imaging with plain T2-weighted and T1-weighted fast field echo sequences before and 24 hours after injection of Gadophrin-3, a new necrosis-avid contrast agent. Tumor necrosis on MR images was quantified by means of a dedicated segmentation program and was correlated with histologic findings.In all tumors a central necrosis was revealed by histopathologic analysis, and central enhancement was seen with Gadophrin-3 on T1-weighted images. Small tumors (diameter, < 1 cm) showed an inhomogeneous central enhancement, whereas larger tumors (diameter, > 1 cm) enhanced mainly in the periphery of necrotic tissue. Plain T2-weighted images showed a hyperintense central area in only three of 20 cases with a large central necrosis.Gadophrin-3-enhanced T1-weighted images are superior to plain T2-weighted images for the detection of necrosis in a murine tumor xenograft model.

    View details for Web of Science ID 000182566800003

    View details for PubMedID 12755535

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