Lynn Million

Publication Details

  • Outcome of patients with localized orbital sarcoma who relapsed following treatment on Intergroup Rhabdomyosarcoma Study Group (IRSG) Protocols-III and -IV, 1984-1997: A report from the Children's Oncology Group PEDIATRIC BLOOD & CANCER Raney, B., Huh, W., Hawkins, D., Hayes-Jordan, A., Million, L., Rodeberg, D., Teot, L., Anderson, J. 2013; 60 (3): 371-376

    Abstract:

    We wanted to ascertain patterns of recurrence, re-treatment, and outcome among 188 eligible patients treated for localized orbital sarcoma on IRSG Protocols III/IV, 1984-1997.Retrospective chart review.Twenty-four of 188 patients (12.8%) developed local (n?=?22) or distant relapse (n?=?2) at 0.057-7.05 years (median, 1.58) after enrollment. Ages at study entry were 0.14-17 years (median, 5 years). Initial tumor operations included biopsy (n?=?20) or gross resection with microscopic residual (n?=?4). Initial tumor diameters were 0.5-7?cm (median, 3). Pathologic subtypes were embryonal rhabdomyosarcoma (ERMS, n?=?19), sarcoma not otherwise specified (n?=?2), and alveolar RMS, botryoid ERMS, or undifferentiated sarcoma (n?=?1 each). Initial treatment included vincristine/dactinomycin (n?=?24) including an alkylator (n?=?4) and radiotherapy (RT, n?=?21). Twenty patients responded, 14 completely, 6 partially. After recurrence, patients underwent orbital exenteration (n?=?10), enucleation (2), tumor excision (3), or biopsy (1); 7 had no operation, and 1 had no data. Post-relapse chemotherapy included combinations of etoposide (n?=?14 patients), doxorubicin (14), ifosfamide (12), cyclophosphamide (7), and dacarbazine (n?=?1). Six patients received RT, including four previously treated and two not irradiated initially. Two patients died; one at 1.79 years after contralateral brain metastasis followed by local recurrence, and another at 2.49 years after multiple local recurrences. Twenty-two patients (91.7%) survived sarcoma-free for 0.04-17 years (median, 6.9) after relapse, and 18 of 22 (82%) were alive ?5 years after relapse.Survival following recurrent localized orbital sarcoma appears likely after vigorous re-treatment given with curative intent.

    View details for DOI 10.1002/pbc.24289

    View details for Web of Science ID 000313727000005

    View details for PubMedID 22961750

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