James Lock

Publication Details

  • Eating Disorders in Youth: Diagnostic Variability and Predictive Validity INTERNATIONAL JOURNAL OF EATING DISORDERS Loeb, K. L., Le Grange, D., Hildebrandt, T., Greif, R., Lock, J., Alfano, L. 2011; 44 (8): 692-702


    The primary aim was to examine the utility of DSM-IV criteria in predicting treatment outcome in a sample of adolescents with eating disorders.We (a) descriptively compared the baseline rates of anorexia nervosa (AN) and bulimia nervosa (BN) across multiple reference points for diagnostic criteria, (b) using ROC curve analyses, assessed the sensitivity and specificity of each diagnostic criterion in predicting clinical outcome, and (c) with logistic regression analyses, examined the incremental predictive value of each criterion.Results show a high degree of variability in the baseline diagnostic profiles as a function of the information used to inform each DSM-IV criterion. For AN, Criterion A yielded the best predictive validity, with Criteria B-D providing no significant incremental value. For BN, none of the measures had a significant AUC, and results from logistic regression analyses showed that none of the indicators were robust in predicting outcome.For AN, the existing Criterion A is appropriate for children and adolescents, and is sufficient to predict outcome in the context of active refusal to maintain a normal weight as well as multiple informants and behavioral indicators of the psychological aspects of AN. For BN, predictive validity could not be established.

    View details for DOI 10.1002/eat.20872

    View details for Web of Science ID 000297309300004

    View details for PubMedID 22072406

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