Anson Lowe

Publication Details

  • Characterization of an alternatively spliced isoform of rat vesicle associated membrane protein-2 (VAMP-2) FEBS LETTERS Mandic, R., Lowe, A. W. 1999; 451 (2): 209-213


    VAMPs are vesicle associated membrane proteins that are essential for secretion. A spliced isoform of rat VAMP-2, called VAMP-2B, is characterized in this study. The VAMP-2B transcript is the result of alternative RNA splicing in which an intron is retained. The predicted amino acid sequence of VAMP-2B differs from VAMP-2 at its carboxy-terminal end. Because recent studies have shown that VAMP's carboxy-terminal end influences the protein's sorting, the location of myc-epitope tagged VAMP-2B in PC12 cells was determined. Subcellular fractionation showed colocalization of myc-VAMP-2B and endogenous VAMP-2. Thus alternative RNA splicing does not affect VAMP-2 sorting in PC12 cells.

    View details for Web of Science ID 000080596800023

    View details for PubMedID 10371166

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