Krisa Van Meurs

Publication Details

  • Inhaled nitric oxide in term and near-term infants: Neurodevelopmental follow-up of The Neonatal Inhaled Nitric Oxide Study Group (NINOS) JOURNAL OF PEDIATRICS Finer, N. N., Vohr, B. R., Robertson, C. M., Ehrenkranz, R. A., Verter, J., Wright, L. L., Hoffman, H. J., Walsh-Sukys, M. C., Dusick, A. M., Fleisher, B. E., Steichen, J., Laadt, G., Yolton, K., Delaney-Black, V., Vohr, B. R., Whitfield, M. F., Blayney, M. P., Sauve, R. S., Casiro, O. G., Saigal, S., Riley, S. P., Robertson, C. M., Sankaran, K., Gosselin, R., Reynolds, A., Stork, E., Gorjanc, E., Verter, J., Powers, T., Sokol, G. M., Appel, D., Wright, L. L., Van Meurs, K., Rhine, W., Ball, B., Brilli, R., Moles, L., Crowley, M., Backstrom, C., Crouse, D., Hudson, T., Konduri, G. G., Bara, R., Kleinman, M., Hensmann, A., Rothstein, R. W., Ehrenkranz, R. A., Solimano, A., Germain, F., Walker, R., Ramirez, A. M., Singhal, N., Bourcier, L., Fajardo, C., Cook, V., Kirpalani, H., Monkman, S., Johnston, A., Mullahoo, K., Finer, N. N., Peliowski, A., Etches, P., Kamstra, B., Sankaran, K., Riehl, A., Blanchard, P., Gouin, R., Wearden, M. E., Gomez, M. R., Moon, Y. S., Avery, G. B., D'Alton, M. E., Bracken, M. B., Catz, C., Gleason, C. A., Maguire, M., Redmond, C. K., Sinclair, J. C., Verter, J. 2000; 136 (5): 611-617


    Inhaled nitric oxide (INO) improved oxygenation and reduced the occurrence of death or extracorporeal membrane oxygenation in term and near-term hypoxic neonates. We report the results of neurodevelopmental follow-up of infants enrolled in the NINOS trial.Hypoxic infants >/=34 weeks' gestation and <14 days of age were randomized to 20 ppm INO or 100% oxygen as control. Comprehensive neurodevelopmental assessment of survivors occurred at 18 to 24 months of age.A total of 235 infants were enrolled in the original trial. There were 36 deaths, 20 of 121 infants in the control group and 16 of 114 infants in the INO-treated group. Of the 199 surviving infants, 173 (86.9%) were seen for follow-up (88 members of the control group and 85 members of the INO-treated group), and 135 infants were normal (69 [79.3%] members of the control group and 66 [77.6%] members of the INO-treated group). Twenty-two infants had sensorineural hearing loss (12 members of the control group and 10 members of the INO-treated group). Moderate to severe cerebral palsy occurred in 13 infants (7 infants in the control group and 6 infants in the INO-treated group). Mental developmental index scores (87 +/- 18.7 in the control group vs 85 +/- 21.7 in the INO-treated group) and psychomotor developmental index scores (93.6 +/- 17.5 in the control group vs 85.7 +/- 21.2 in the INO-treated group) were not different. A total of 29.6% of the control group compared with 34.5% of the INO-treated group had at least one disability. Infants with congenital diaphragmatic hernia, enrolled in a separate but parallel trial, had similar outcomes with a higher incidence of sensorineural hearing loss.Inhaled nitric oxide is not associated with an increase in neurodevelopmental, behavioral, or medical abnormalities at 2 years of age.

    View details for Web of Science ID 000086985900011

    View details for PubMedID 10802492

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