Manpreet K. Singh, MD MS

Publication Details

• Reward processing in adolescents with bipolar I disorder.

  Singh MK, Chang KD, Kelley RG, Cui X, Sherdell L, Howe ME, Gotlib IH, Reiss AL. J Am Acad Child Adolesc Psychiatry. 2013; 52 (1): 68-83

  Bipolar disorder (BD) is a debilitating psychiatric condition that commonly begins in adolescence, a developmental period that has been associated with increased reward seeking. Because youth with BD are especially vulnerable to negative risk-taking behaviors, understanding the neural mechanisms by which dysregulated affect interacts with the neurobehavioral processing of reward is clearly important. One way to clarify how manic symptoms evolve in BD is to "prime" the affect before presenting rewarding stimuli. The objective of this study was to investigate the neural effects of an affective priming task designed to positively induce mood before reward processing in adolescents with and without BD.

  PubMedID: 23265635