Michael Amylon

Publication Details

  • Comparison of two doses of intravenous immunoglobulin after allogeneic bone marrow transplants BONE MARROW TRANSPLANTATION Abdel-Mageed, A., Graham-Pole, J., del Rosario, M. L., Longmate, J., Ochoa, S., Amylon, M., Elfenbein, G. J., Janiec, J., Jansen, J., Lazarus, H. M. 1999; 23 (9): 929-932


    Intravenous immunoglobulin has been used after bone marrow transplants to prevent infections and acute graft-versus-host disease. However, the minimum dose required for protection is unknown. This may have significant economic implications. A multicenter randomized clinical trial compared the impact of two intravenous immunoglobulin doses on systemic infections and acute graft-versus-host disease in transplant recipients. Either 250 mg/kg or 500 mg/kg was given weekly from day -8 to day +111. Multivariate analysis was used to assess the effect of dose and other risk factors on event-free survival, systemic infection, and acute graft-versus-host disease. The two-dose cohorts had similar event-free survival and infection frequencies. The higher dose was associated with less acute graft-versus-host disease (P = 0.03).

    View details for Web of Science ID 000080097200011

    View details for PubMedID 10338049

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